How do Hsp90 co-chaperones regulate virulence?
Yeast Hsp90 achieves client specificity and chaperone activity only when acting in concert with nine co-chaperones. In Candida albicans, co-chaperone levels vary in developmental stages associated with virulence, resembling Hsp90 levels. Given Hsp90’s central role in virulence, we ask if co-chaperones affect virulence and development in C. albicans.
This project examines the contributions of non-essential co-chaperones to virulence, stress response, and development and investigates their developmental regulation on the transcriptional and translational level.