Hsp90 co-chaperones and their role in fungal virulence

Hsp90 co-chaperones and their role in fungal virulence

Yeast Hsp90 acts in concert with up to 13 co-chaperones that modulate client specificity and ATPase activity. These co-chaperones are much less conserved than Hsp90 and their role in virulence remains largely enigmatic. Here we ask, if these co-chaperones regulate Candida virulence and if targeting them, rather than Hsp90, would be a viable alternative to block Candida virulence.

Our Marie Sklodowska-Curie Action funded research project investigated the role of Hsp90 co-chaperones in Candida virulence and genome integrity. As part of this project, we:

  • demonstrated that non-essential co-chaperones regulate different facets of Candida virulence, including biofilm formation and virulence in an invertebrate model of fungal virulence (Lyons et al., manuscript in preparation),
  • showed that Hsp90 is essential for genome diversification in this obligate diploid yeast (Dong et al., manuscript in preparation).

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